Animal Health Diagnostic Center

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Comparative Coagulation


Research and Publications

Coagulation Lab Areas of Research

  • Naturally occurring hemostatic disorders in animals
    • Hereditary factor deficiencies and platelet defects
    • Acquired thrombotic disorders and antithrombotic therapies
  • Clinical assay development and validation 

Coagulation Lab Research and Collaborative Projects

Brooks MB, Turk JR, Guerrero A, Narayanan PK, Nolan JP, Besteman EG, Wilson
DW, Thomas RA, Fishman CE, Thompson KL, Ellinger-Ziegelbauer H, Pierson JB,
Paulman A, Chiang AY, Schultze AE. Non-Lethal Endotoxin Injection: A Rat Model of
Hypercoagulability. PLoS One. 2017 Jan 12;12(1):e0169976.
PubMed PMID: 28081568 http://www.ncbi.nlm.nih.gov/pubmed/28081568

Dixon-Jimenez AC, Brainard BM, Brooks MB, Nie B, Arnold RD, Loper D, Abrams JC, Rapoport GS. Pharmacokinetic and pharmacodynamic evaluation of oral rivaroxaban in healthy adult cats. J Vet Emerg Crit Care 2016;26:619-29.
PubMed PMID: 27599304. http://www.ncbi.nlm.nih.gov/pubmed/27599304

Manion JS, Thomason JM, Langston VC, Claude AK, Brooks MB, Mackin AJ, Lunsford KV. Anticoagulant effects of inhaled unfractionated heparin in the dog as determined by partial thromboplastin time and factor Xa activity. J Vet Emerg Crit Care 2016;26:132-6
PubMed PMID: 26194053.  http://www.ncbi.nlm.nih.gov/pubmed/26194053

Fletcher D, Rozanski L, Delaforcade A, Brainard B, Brooks MB. Assessment of the relationships among coagulopathy, hyperfibrinolysis, plasma lactate, and protein C in dogs with spontaneous hemoperitioneum. J Vet Emerg Crit Care 2016;26:41-51.
PubMed PMID: 26220266.  http://www.ncbi.nlm.nih.gov/pubmed/26220266

Frye C, Enders A, Brooks M, Struble AM, Wakshlag J. Assessment of canine platelet-rich plasma produced with a commercial centrifugation and platelet recovery kit. Vet Comp Orthop Traumatol 2016;29:14-19.
PubMed PMID: 26194053. http://www.ncbi.nlm.nih.gov/pubmed/26194053

Brooks MB, Catalfamo JL, MacNguyen R, Tim D, Fancher S, McCardle JA. A TMEM16F point mutation causes an absence of canine platelet TMEM16F and ineffective activation and death-induced phospholipid scrambling. J Thromb Haemost. 2015 Dec;13(12):2240-52.
PMID: 26414452.  http://www.ncbi.nlm.nih.gov/pubmed/26414452

Conner B, Hanel R, Brooks MB, Cohn L, Birkenheuer A. Coagulation abnormalities in 5 cats with naturally occurring cytauxzoonosis. J Vet Emerg Crit Care 2015;25:538-545.
PMID 2 26082008  http://www.ncbi.nlm.nih.gov/pubmed/26082008

Aslanian ME, Sharp CR, Rozanski EA, de Laforcade AM, Rishniw M, Brooks MB. Clinical outcome after diagnosis of hemophilia A in dogs. J Am Vet Med Assoc. 2014;245:677-83.
PMID 25181272 http://www.ncbi.nlm.nih.gov/pubmed/25181272

Springer NL, Smith E, Brooks MB, Stokol, T. Flow cytometric detection of circulating platelet-derived microparticles in clinically healthy adult horses. Am J Vet Res 2014;75:879-885.
PMID: 25255176  http://www.ncbi.nlm.nih.gov/pubmed/25255176

Watts AE, Ness SL, Divers TJ, Fubini SL, Frye AH, Stokol T, Cummings KJ, Brooks MB. Effects of clopidogrel on horses with experimentally induced endotoxemia. Am J Vet Res. 2014;75(8):760-9.
PMID: 25061708  http://www.ncbi.nlm.nih.gov/pubmed/25061708

LeVine DN, Birkenheuer AJ, Brooks MB, Nordone SK, Bellinger DA, Jones SL, Fischer TH, Oglesbee SE, Frey K, Brinson NS, Peters AP, Marr HS, Motsinger-Reif A, Gudbrandsdottir S, Bussel JB, Key NS. A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs? Br J Haematol. 2014.
PMID: 25039744  http://www.ncbi.nlm.nih.gov/pubmed/25039744

Grochowsky AR, Rozanski EA, de Laforcade AM, Sharp CR, Meola DM, Schavone JJ,  Brooks MB. An ex vivo evaluation of efficacy of refrigerated canine plasma. J Vet Emerg Crit Care  2014;24:388-397.
PMID: 25039603 . http://www.ncbi.nlm.nih.gov/pubmed/25039603

Brooks MB, Divers TJ, Watts AE, Ness SL, Frye AH, Stokol T, Fubini SL. Effects of clopidogrel on the platelet activation response in horses. Am J Vet Res. 2013  Sep;74(9):1212-22.  
PMID: 25061708  http://www.ncbi.nlm.nih.gov/pubmed/25061708

Bebar KN, Sinnott V, Brooks MB. Recurrent hemorrhage caused by type 3 von Willebrand disease in a domestic long-haired cat. J Vet Emerg Crit Care 2014;24(3):326-31.  
PMID: 24957149. http://www.ncbi.nlm.nih.gov/pubmed/24957149

Walton JE, Hale AS, Brooks MB, Boag AK, Barnett W, Dean R. Coagulation factor  and hemostatic protein content of canine plasma after storage of whole blood at ambient temperature. J Vet Intern Med. 2014 Mar;28(2):571-5.
PMID: 24467263.  http://www.ncbi.nlm.nih.gov/pubmed/24467263

Winfield LS, Brooks MB. Hemorrhage and blood loss-induced anemia associated with an acquired coagulation factor VIII inhibitor in a Thoroughbred mare. J Am Vet Med Assoc. 2014 Mar 15;244(6):719-23.
PMID: 24568115. http://www.ncbi.nlm.nih.gov/pubmed/24568115

Abdelgader AG, Al Momen AKM, Alhaider A, Brooks MB, Catalfamo JL, Al Haidari A, Hussain MF. Anti-haemophilic factor (Factor VIII) and thrombin generation in camel plasma-a comparative studies with humans. Canadian Vet J 2013;77:150-157.
PMID: 24082408 http://www.ncbi.nlm.nih.gov/pubmed/24082408

Pierson JB, Berridge BR, Brooks MB, Kreher K, Koerner J, Schultze AE, Sarazan, RD, Valentin JP, Vargas HM, Pettit SD. A Public-Private Consortium Advances Cardiac Safety Evaluation: Achievements of the HESI Cardiac Safety Technical Committee J Pharmacol Toxicol Methods 2013;68:7-12.
PMID: 23567075 http://www.ncbi.nlm.nih.gov/pubmed/23567075

Helmond SE, Catalfamo JL, Brooks MB. Flow cytometric detection and procoagulant activity of circulating canine platelet-derived microparticles. Am J Vet Res. 2013 Feb;74(2):207-15.
PMID: 23363344 http://www.ncbi.nlm.nih.gov/pubmed/23363344

Mayhew PM, Savigny MR, Otto CM, Brown DC, Brooks MB, Bentley AM, Runge JF, Callan MB. Evaluation of coagulation in dogs with partial or complete extra-hepatic biliary tract obstruction using thromboelastography. J Am Vet  Med Assoc. 2013 Mar 15;242(6):778-85.
PMID 23445288 http://www.ncbi.nlm.nih.gov/pubmed/23445288

Schultze AE, Walker DB, Turk JR, Tarrant JM, Brooks MB, Pettit SD. Current practices in preclinical drug development: gaps in hemostasis testing to assess risk of thromboembolic injury. Toxicol Pathol. 2012 Toxicol Pathol. 2013;41(3):445-53.
PMID 22991386 http://www.ncbi.nlm.nih.gov/pubmed/22991386

Jandrey KE, Norris JW, Tucker M, Brooks MB. Clinical characterization of canine platelet procoagulant deficiency (Scott Syndrome). J Vet Intern Med. 2012  Nov-Dec;26(6):1402-7.
PMID 23061683 http://www.ncbi.nlm.nih.gov/pubmed/23061683

Donahue, SM, Brooks M, Otto CM. Examination of hemostatic parameters to detect hypercoagulability in dogs with severe protein-losing nephropathy. J Vet Emerg Crit Care (San Antonio). 2011 Aug;21(4):346-55. doi: 10.1111/j.1476-4431.2011.00656.x.
PMID 21827592 http://www.ncbi.nlm.nih.gov/pubmed/21827592

Watts AE, Fubini SL, Todhunter RJ, Brooks MB. Comparison of plasma and peritoneal indices of fibrinolysis between foals and adult horses with and without colic. Am J Vet Res. 2011 Nov;72(11):1535-40.
PMID 22023133 http://www.ncbi.nlm.nih.gov/pubmed/22023133

Sharpe KS, Center SA, Randolph JF, Brooks MB, Warner KL, Stokol T, Barr, SC, Felippe MJ. Influence of treatment with ultralow-dose aspirin on platelet aggregation as measured by whole blood impedence aggregometery and platelet P-selectin expression in clinically normal dogs. Am J Vet Res. 2010 Nov;71(11):1294-1304.
PMID 21034320 http://www.ncbi.nlm.nih.gov/pubmed/21034320

Booth CJ, Brooks MB, Rockwell S, Murphy JW, Rinder HM, Zelterman D, Paidas MJ, Compton SR, Marks PW. WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. J Thromb Haemost. 2010 Nov;8(11):2472-77. doi: 10.1111/j.1538-7836.2010.03978.x.
PMID 20626616 http://www.ncbi.nlm.nih.gov/pubmed/20626616

Yaxley PE, Beal MW, Jutkowitz LA, Hauptman JG, Brooks MB, Hale AS, Parr A. Comparative stability of canine and feline hemostatic proteins in freeze-thaw-cycled fresh frozen plasma. J Vet Emerg Crit Care (San Antonio). 2010 Oct;20(5):472-78. doi: 10.1111/j.1476-4431.2010.00563.x.
PMID 20955297 http://www.ncbi.nlm.nih.gov/pubmed/20955297

Booth CJ, Brooks MB, Rockwell S. Spontaneous coagulopathy in inbred WAG/RijYcb rats. Comp Med. 2010 Feb;60(1):25-30.
PMID 20158945 http://www.ncbi.nlm.nih.gov/pubmed/20158945

Brooks M, Etter K, Catalfamo J, Brisbin A, Bustamante C, Mezey J. A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott syndrome) to canine chromosome 27. Gene. 2010 Jan 15;450(1-2):70-5.
PMID 19854246 http://www.ncbi.nlm.nih.gov/pubmed/19854246

Studies Utilizing Coagulation Lab Services

White CR, Langston C, Hohenhaus AE, Lamb K, Hackner S, Fox PR. Evaluation of the relationship between clinical variables and thromboelastographic findings in dogs with protein-losing nephropathy. J Vet Emerg Crit Care (San Antonio). 2016 Jan;26(1):74-9.
PMID: 26458243. http://www.ncbi.nlm.nih.gov/pubmed/26458243

Gerlach TJ, Bandt C, Conner B, Ball RL. Establishment of reference values for  various coagulation tests in healthy Florida manatees (Trichechus manatus latirostris) and evaluation of coagulation in debilitated manatees during rehabilitation. J Am Vet Med Assoc. 2015 Nov 1;247(9):1048-55
PMID: 26480015  http://www.ncbi.nlm.nih.gov/pubmed/26480015

Adamantos S, Waters S, Boag A. Coagulation status in dogs with naturally occurring Angiostrongylus vasorum infection. J Small Anim Pract. 2015 Aug;56(8):485-90.
PMID: 26032443. http://www.ncbi.nlm.nih.gov/pubmed/26032443

Pashmakova MB, Barr JW, Bishop MA. Stability of hemostatic proteins in canine fresh-frozen plasma thawed with a modified commercial microwave warmer or warm water bath. Am J Vet Res. 2015 May;76(5):420-5.
PMID 25909374 http://www.ncbi.nlm.nih.gov/pubmed/25909374

Fletcher DJ, Blackstock KJ, Epstein K, Brainard BM. Evaluation of tranexamic acid and ϵ-aminocaproic acid concentrations required to inhibit fibrinolysis in plasma of dogs and humans. Am J Vet Res. 2014 Aug;75(8):731-8.
PMID 25061704  http://www.ncbi.nlm.nih.gov/pubmed/25061704

Holowaychuk MK, Hanel RM, Wood RD, Rogers L, O’Keefe K, Monteith G. Prospective multicenter evaluation of coagulation abnormalities in dogs following severe acute trauma. J Vet Emerg Crit Care (San Antonio). 2014 Jan-Feb;24(1):93-104. doi: 10.1111/vec.12141.
PMID 24410816 http://www.ncbi.nlm.nih.gov/pubmed/24410816

Epstein KL, Bergren A, Giguère S, Brainard BM. Cardiovascular, colloid osmotic pressure, and hemostatic effects of 2 formulations of hydroxyethyl starch in healthy horses. J Vet Intern Med. 2014 Jan-Feb;28(1):223-33. PubMed.
PMID: 24428324. http://www.ncbi.nlm.nih.gov/pubmed/24428324

Kelley D, Lester C, Delaforcade A, Webster CR. Thromboelastographic evaluation of dogs with congenital portosystemic shunts. J Vet Intern Med. 2013 Sep;27(5):1262-7.
PMID: 23815243 http://www.ncbi.nlm.nih.gov/pubmed/3815243

Fletcher DJ, Brainard BM, Epstein K, Radcliffe R, Divers T. Therapeutic plasma concentrations of epsilon aminocaproic acid and tranexamic acid in horses. J Vet  Intern Med. 2013 Nov-Dec;27(6):1589-95.
PMID 24118238  http://www.ncbi.nlm.nih.gov/pubmed/24118238

Pace SL, Creevy KE, Krimer PM, Brainard BM. Assessment of coagulation and potential biochemical markers for hypercoagulability in canine hyperadrenocorticism. J Vet Intern Med. 2013 Sep;27(5):1113-20.
PMID: 23952553 http://www.ncbi.nlm.nih.gov/pubmed/23952553

Urban R, Guillermo Couto C, Cristina Iazbik M. Evaluation of hemostatic activity of canine frozen plasma for transfusion by thromboelastography. J Vet Intern Med. 2013 Jul;27(4):964-9.
PMID: 23663247  http://www.ncbi.nlm.nih.gov/pubmed/23663247

Lennon EM, Hanel RM, Walker JM, Vaden SL. Hypercoagulability in dogs with protein-losing nephropathy as assessed by thromboelastography. J Vet Intern Med.  2013 May;27(3):462-8.
PMID: 23528002. http://www.ncbi.nlm.nih.gov/pubmed/23528002

Blong AE, Epstein KL, Brainard BM. In vitro effects of three formulations of hydroxyethyl starch solutions on coagulation and platelet function in horses. Am  J Vet Res. 2013 May;74(5):712-20.
PMID: 23627384  http://www.ncbi.nlm.nih.gov/pubmed/23627384

Bentley AM, Mayhew PD, Culp WT, Otto CM. Alterations in the hemostatic profiles of dogs with naturally occurring septic peritonitis. J Vet Emerg Crit Care (San Antonio). 2013 Jan;23(1):14-22. doi: 10.1111/vec.1 2013. Epub 2013 Jan 14. PubMed.
PMID: 23317011  http://www.ncbi.nlm.nih.gov/pubmed/23317011

Babski DM, Brainard BM, Ralph AG, Pittman JR, Koenig A. Sonoclot® evaluation of single- and multiple-dose subcutaneous unfractionated heparin therapy in healthy adult dogs. J Vet Intern Med. 2012 May-June;26(3):631-38. doi: 10.1111/j.1939-1676.2012.00907.x.
PMID 22435404 http://www.ncbi.nlm.nih.gov/pubmed/22435404

Fiakpui NN, Hogan DF, Whittem T, Green HW 3rd, Shipley EQ, Sederquist KA. Dose determination of fondaparinux in healthy cats. Am J Vet Res. 2012 Apr;73(4):556-61. doi: 10.2460/ajvr.73.4.556.
PMID 22452504 http://www.ncbi.nlm.nih.gov/pubmed/22452504

Vilar Saavedra P, Lara García A, Zaldívar López S, Couto G. Hemostatic abnormalities in dogs with carcinoma: a thromboelastographic characterization of hypercoagulability. Vet J. 2011 Nov;190(2):e78-83.
PMID 21454111 http://www.ncbi.nlm.nih.gov/pubmed/21454111

Dawson DR, DeFrancisco RJ, Stokol T. Reference intervals for hematologic and coagulation tests in adult alpacas (Vicugna pacos). Vet Clin Pathol. 2011 Dec;40(4):504-12. doi: 10.1111/j.1939-165X.2011.00359.x.
PMID 22092869 http://www.ncbi.nlm.nih.gov/pubmed/22092869

Van De Wiele CM, Hogan DF, Green HW 3rd, Sederquist KD. Antithrombotic effect of enoxaparin in clinically healthy cats: a venous stasis model. J Vet Intern Med. 2010 Jan-Feb; 24(1):185-91.
PMID 19912519 http://www.ncbi.nlm.nih.gov/pubmed/19912519

Rattner BA, Horak KE, Warner SE, Johnston JJ. Acute toxicity of diphacinone in Northern bobwhite: effects on survival and blood clotting. Ecotoxicol Environ Saf. 2010 Sep;73(6):1159-64.
PMID 20580432 http://www.ncbi.nlm.nih.gov/pubmed/20580432

McLean NS, Ward DA, Hendrix DV, Donnell RL, Ilha MR. Ligneous conjunctivitis secondary to congenital plasminogen deficiency in a dog. J Am Vet Med Assoc. 2008 Mar 1;232(5):715-21.
PMID 18312178 http://www.ncbi.nlm.nih.gov/pubmed/18312178

Scott KC, Hansen BD, DeFrancesco TC. Coagulation effects of low molecular weight heparin compared with heparin in dogs considered to be at risk for clinically significant venous thrombosis. J Vet Emerg Crit Care (San Antonio). 2009 Feb;19(1):74-80.
PMID: 19691587. http://www.ncbi.nlm.nih.gov/pubmed/19691587